Synonyms: AGA
Related tests: Anti-endomysial antibodies, anti-transglutaminase antibodies, HLA genetic test for coeliac disease
Clinical significance
Coeliac disease is an enteropathy that mainly affects the proximal small intestine, causing malabsorption. It is caused by intolerance to gluten, found in wheat and other cereals. Anti-gliadin antibodies (AGA) are IgA/IgG immunoglobulins used alongside anti-endomysial (EMA) and anti-transglutaminase (TGA) antibodies in the serological diagnosis of coeliac disease. AGA are directed against gliadin, a soluble fraction of gluten; they are fairly sensitive but less specific than EMA and TGA, and are more useful for monitoring a gluten-free diet.
Clinical indications
Coeliac disease
Sample type
The patient must have a blood sample taken.
Preparation
You must fast for at least 8 hours; a small amount of water is allowed.
Notes
A fall in IgG and IgA AGA titres after starting a gluten-free diet indicates a good response in patients with coeliac disease. In congenital IgA deficiency and in very young children the test may be negative.