Related tests: anti-DNA, ENA
Clinical significance
Anti-centromere antibodies are antinuclear autoantibodies directed against the antigenic structure of the centromere. They are positive in CREST syndrome, a relatively benign form of scleroderma associated with calcinosis, Raynaud’s phenomenon, oesophageal dysmotility, sclerodactyly and telangiectasia. The antibodies may also rarely be present in systemic lupus erythematosus, Sjögren’s syndrome and rheumatoid arthritis.
Clinical indications
Scleroderma, CREST syndrome.
Sample type
The patient must have a blood sample taken.
Preparation
You must fast for at least 8 hours; a small amount of water is allowed. You must have been standing or sitting upright for at least 30 minutes.
Notes
Anti-centromere antibodies are found in 70-90% of cases of CREST syndrome. Their presence is useful in classifying scleroderma, as these autoantibodies are linked to forms of scleroderma with a better prognosis. Anti-centromere antibodies and anti-Scl-70 antibodies (the latter linked to more severe forms of scleroderma) are very rarely found in the same patient.