Synonyms: ACTIVATED PROTEIN C RESISTANCE
Related tests:
MTHFR – FACTOR V LEIDEN
Clinical significance
Activated protein C resistance is a condition also known as Leiden syndrome. It is caused by a mutation (the Leiden mutation of clotting factor V) that makes clotting factor V ineffective.
In the European population about 5% of people carry the Leiden mutation.
20-40% of patients with deep vein thrombosis carry at least one Leiden mutation.
Leiden syndrome is a relatively common condition: in Italy alone about 2,000,000 people (3-4% of the population) carry the mutation.
Test turnaround time: 15 days
Clinical indications
Diagnostic use: Leiden syndrome is one of the most common inherited causes of a predisposition to deep vein thrombosis. Venous thrombosis occurs when a small blood clot forms inside a vein and sticks to its wall, partly or completely blocking the flow of blood.
The clot is called a thrombus.
NB: It is very important to check this value before taking oral contraceptives.
Oral contraceptives (oestrogens and progestogens) can in fact cause venous thrombosis or other arterial cardiovascular disorders in people at risk.
Notes
APCR REFERENCE VALUES UNIT OF MEASUREMENT
ACTIVATED PROTEIN C RESISTANCE
2.4 – 3.5