Synonyms: OC
Related tests: Calcitonin, PTH, Vitamin D, Alkaline phosphatase
Clinical significance
Osteocalcin, a protein whose production depends on vitamin K, can make up as much as 3% of bone protein. Osteocalcin is found only in bone tissue and is produced by osteoblasts. It is thought to be involved in the mineralisation process, probably under the influence of the other hormones that regulate calcium metabolism: calcitonin, parathyroid hormone and vitamin D.
Clinical indications
Osteocalcin is a specific marker of bone disease. Osteocalcin levels can be used as an index in assessing treatment.
Sample type
The patient must have a blood sample taken.
Preparation
You must fast for at least 8 hours; a small amount of water is allowed.
Notes
Raised osteocalcin levels are seen in bone diseases characterised by increased bone turnover, such as Paget’s disease, cancer with bone metastases, primary hyperparathyroidism and renal osteodystrophy.